Parussini, F.P., Tang, Q., Moin, S.M., Mital, J.M., Urban, S., and Ward, G.E. (2012) Intramembrane proteolysis of Toxoplasma Apical Membrane Antigen 1 facilitates        

            host cell invasion but is dispensable for replication. Proc Natl Acad Sci U S A 109: 7463-7468. PMCID: PMC3358886 [Available on 2012/11/8]


Dotzler Barkhuff, W., Gilk, S.D., Whitmarsh, R., Tilley, L.D., Hunter, C., Ward, G.E. (2011) Targeted Disruption of TgPhIL1 in Toxoplasma gondii Results in Altered

            Parasite Morphology and Fitness. PLoS ONE 6: e23977. PMCID: PMC3162014


Hall C.I., Reese M.L., Weerapana E., Child M.A., Bowyer P.W., Albrow V.E., Haraldsen J.D., Phillips M.R., Sandoval E.D., Ward G.E., Cravatt B.F., Boothroyd J.C.,

            Bogyo M. (2011) Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. Proc Natl Acad Sci USA

            108:10568-73. PMCID: PMC3127939


Sheiner, L., Santos, J.M, Klages, N., Parussini F.,  Jemmely, N., Friedrich, N., Ward, G. E.,  Soldati-Favre, D. (2010) Toxoplasma gondii transmembrane microneme

            proteins and their modular design. Molec. Microbiol. 77, 912-929. PMCID: PMC2982875


Heaslip, A.T., Leung, J.M., Carey, K.L., Catti, F., Warshaw, D.M., Westwood, N.J., Ballif, B.A., and Ward G.E. (2010) A small-molecule inhibitor of T. gondii motility      

            induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity. PLoS Pathogens 6, e1000720. PMCID: PMC2800044


Walton, J.G.A., Patterson, S. Liu, G., Haraldsen, J.D., Hollick, J.J., Slawin, A.M.Z., Ward, G.E., and Westwood, N.J. (2009) Synthesis and Biological Evaluation of Functionalised Tetrahydro-β-carboline Analogues as Inhibitors of Toxoplasma gondii Invasion. Org. Biomol. Chem. 15, 3049-3060.


Haraldsen, J.D., Liu, G., Botting, C.H., Walton, J.G.A., Storm, J., Phalen, T.J., Kwok, L.Y., Soldati-Favre, D., Heintz, N.H., Muller, S., Westwood, N.J. and Ward, G. E. (2009) Identification of Conoidin A as a covalent inhibitor of peroxiredoxin II. Org. Biomol. Chem. 15, 3040-3048. PMCID: PMC3043594


Gilk, S.D, Gaskins, E., Ward, G.E., and Beckers, C.J.M. (2009) GAP45 phosphorylation controls assembly of the Toxoplasma myosin XIV complex. Euk. Cell 8, 190-196. PMCID: 2643604


Kato, N., Sakata, T., Breton, G., Le Roch, K. G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K., Johnson, J., Kumar, K. A., Marr, F., Mason, D., McNamara, C., Plouffe, D., Ramachandran, V., Spooner, M., Tuntland, T., Zhou, Y., Peters, E. C., Chatterjee, A., Schultz, P. G., Ward, G. E., Gray, N., Harper, J., and Winzeler, E.A. (2008) Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat. Chem. Biol. 4, 347-356.


Evans, K.M., Haraldsen, J.D., Pearson, R.J., Slawin,  A.M.Z, Ward, G.E. and Westwood, N.J. (2007) Synthesis and chemical characterisation of target identification reagents based on an inhibitor of human cell invasion by the parasite Toxoplasma gondii. Org. Biomol. Chem. 5, 2063-2069.


Morgan, R.E., Evans, K.M., Patterson, S., Catti, F. Ward, G.E., and Westwood, N.J. (2007) Targeting Invasion and Egress: From tools to drugs? Curr Drug Targets

            8(1), 61-74.


Brydges, S.D., Zhou, X.W., Hunyh, M., Harper, J.M., Mital, J., Ajoble, D., Daubener, W., Ward, G.E., and Carruthers, V.B. (2006) Targeted Deletion of MIC5 Enhances Trimming Proteolysis of Toxoplasma Invasion Proteins. Euk. Cell 5,     2174-2183. PMCID: PMC1694808


Gilk, S.D., Raviv, Y., Hu, K., Murray, J.M., Beckers, C.J.M., and Ward, G.E.  (2006)  Identification of PhIL1, a novel cytoskeletal protein of the Toxoplasma gondii

            pellicle, through photosensitized labeling with [125I]-5-Iodonapthalene-1-azide (INA) Euk. Cell 5: 1622-1634. PMCID: PMC1595352


Mital, J., Schwarz, J. Taatjes, D.J. and Ward, G.E. (2005) Laser Scanning Cytometer-based Assays for Measuring Host Cell Attachment and Invasion by the Human Pathogen, Toxoplasma gondii. Cytometry (Part A) 69A:13–19. PMCID: PMC1428790


Alexander, D.L., Mital, J., Ward, G.E., Bradley, P. and Boothroyd, J. (2005) Identification of the Moving Junction Complex of Toxoplasma gondii: A Collaboration Between Distinct Secretory Organelles. PLoS Pathogens 1, 137-149. PMCID: PMC1262624


Mital, J, Meissner, M, Soldati, D. and Ward, G.E. (2005) Conditional expression of Toxoplasma gondii Apical Membrane Antigen-1 (TgAMA1) demonstrates that TgAMA1 plays a critical role in host cell invasion.  Mol Biol. Cell, 16, 4341-4349. PMCID: PMC1196342


Carey, K.L., Jongco, A., Kim, K. and Ward, G.E. (2004) The Toxoplasma gondii Rhoptry Protein, ROP4, is Secreted into the Parasitophorous Vacuole and Becomes

            Phosphorylated in Infected Cells. Euk. Cell, 3, 1320-30. PMCID: PMC522600


Gaskins, E., Gilk, S., DeVore, N.. Mann, T., Ward, G. and Beckers, C.J. (2004) Identification of the Membrane Receptor of a Class XIV Myosin in Toxoplasma gondii. 

            J. Cell Biol. 165, 383-393PMCID: PMC2172186


Carey, K.L., Westwood, N.J., Mitchison, T.J., and Ward, G.E. (2004) A Small-Molecule Approach to Studying Invasive Mechanisms of Toxoplasma gondii. PNAS 101,

            7433-7438. PMCID: PMC409936


Wichroski, M.J. and Ward, G.E. (2003) Biosynthesis of Glycosylphosphatidylinositol is Essential to the Survival of the Protozoan Parasite Toxoplasma gondii. Euk.

            Cell 2, 1132-1136. PMCID: PMC219362


Ward, G.E., Carey, K.L. and Westwood, N.J. (2002) Using Small Molecules to Study Big Questions in Cellular Microbiology. Cell. Microbiol.  4, 471-482.


Wichroski, M.J., Melton, J., Donahue, C.G., Tweten, R.K., and Ward, G.E. (2002). Clostridium septicum Alpha-Toxin is Active against the Parasitic Protozoan

            Toxoplasma gondii and Targets Members of the SAG Family of GPI-anchored Surface Proteins. Infect.Immun. 70, 4353-4361. PMCID: PMC128134


Donahue, C.G., Carruthers, V., Gilk, S.D. and Ward, G.E. (2000) The Toxoplasma Homolog of Plasmodium Apical Membrane Antigen-1 (AMA-1) is a Microneme

            Protein Secreted in Response to Elevated Intracellular Calcium Levels. Mol. Biochem. Parasitol. 111, 15-30.


Carey, K.L., Donahue, C.G., and Ward, G.E. (2000) Identification and Molecular Characterization of GRA8, a Proline-rich Dense Granule Protein of Toxoplasma

            gondii. Mol. Biochem. Parasitol. 105, 25-37.


Carey, K.L.  and Ward, G.E. (1999) 96-well Plates Providing High Optical Resolution for High-throughput Immunofluorescence-based Screening of Monoclonal

            Antibodies against Toxoplasma gondii.  J. Immunol. Meth. 230, 11-18.


Orfeo, T., Chen, L, Huang, W., Ward, G. and Bateman, E. (1999) Distamycin A Selectively Inhibits Acanthamoeba RNA Synthesis and Differentiation Biochem.            

            Biophys Acta 1446, 273-285.


Mattei, D., Ward, G.E., Langsley, G. and Lingelbach, K. (1999) Novel SecretoryPathways in Plasmodium? Parasitology Today 15, 235-237.


Tardieux, I., Baines, I., Mossakowska, M. and Ward, G.E.  (1998) Actin-binding Proteins of Invasive Malaria Parasites: Regulation of Actin Polymerization by a

            Complex of 32/34-kDa Proteins Associated with Heat Shock Protein-70kDa. Mol. Biochem. Parasitol. 93, 295-308.


Ward, G. E., Tilney, L. G. and Langsley, G.  (1997) Rab GTPases and the Unusual Secretory Pathway of Plasmodium.  Parasitology Today 13, 57-62.


de Castro, F. A., Ward, G.E., Jambou, R., Attal, G., Jaureguiberry, G., Chakarabarti, D., Braun-Breton, C., and Langsley, G. (1996) A Family of Rab G-proteins in

            Plasmodium falciparum and a Detailed Characterisation of PfRab6. Mol. Biochem. Parasitol. 80, 77-88.


Suss-Toby, E., Zimmerberg, J., and Ward, G.E.  (1996) Toxoplasma  Invasion: The Parasitophorous Vacuole is Formed from Host Cell Plasma Membrane and

            Pinches Off  via a Fission Pore. PNAS 93, 8413-8418. PMCID: PMC38685


Ward, G. E. , Fujioka, H., Aikawa, M.  and Miller, L. H. (1994) Staurosporine Inhibits Invasion of Erythrocytes by Malarial Merozoites. Exp. Parasitol., 79, 480-487.


Ward, G. E., Miller, L. H., and Dvorak, J. A. (1993) The Origin of Parasitophorous Vacuole Membrane Lipids in Malaria-infected Erythrocytes. J. Cell Science 106,

            237-248.


Adams, J. H., Hudson, D. E., Torii, M., Ward, G. E., Wellems, T. E., Aikawa, M., and Miller, L.H. (1990) The Duffy Receptor Family of Plasmodium knowlesi  is Located

            within the Micronemes of Invasive Malaria Merozoites. Cell 63, 141-153.


Ward, G.E. and Kirschner, M.W. (1990) Identification of Cell Cycle-Regulated Phosphorylation Sites on Nuclear Lamin C.  Cell 61, 561-577.


Ward, G.E., Moy, G.W., and Vacquier, V.D.  (1986) Phosphorylation of Membrane-bound Guanylate Cyclase of Sea Urchin Spermatozoa. J. Cell Biol. 103, 95- 101. 

            PMCID: PMC2113804


Ward, G. E., Brokaw, C.B., Garbers, D.L., and Vacquier, V.D. (1985) Chemotaxis of Arbacia punctulata  Spermatozoa to Resact, a Peptide from the Egg Jelly Layer. J.

            Cell Biol. 101, 2324-2329.  PMCID: PMC2113998


Ward, G.E., Garbers, D.L., and Vacquier, V.D. (1984) Effects of Extracellular Egg Factors on Sperm Guanylate Cyclase. Science 227, 768-770.


Suzuki, N., Shimomura, H., Radany, E.W., Ramarao, C.S., Ward, G.E., Bentley, J.K., and Garbers, D.L. (1984) A Peptide Associated with Eggs Causes a Mobility Shift

            in a Plasma Membrane Protein of Spermatozoa. J. Biol. Chem. 259, 14874-14879.


Ward, G.E. and Vacquier, V.D. (1983) Dephosphorylation of a Major Sperm Membrane Protein is Induced by Egg Jelly During Sea Urchin Fertilization PNAS 80,

            5578-5582. PMCID: PMC384301


Ward, G.E., Vacquier, V.D. and Michel, S. (1983) The Increased Phosphorylation of Ribosomal Protein S6 in Arbacia punctulata is not a Universal Event in the

            Activation of Sea Urchin Eggs. Develop. Biol. 95, 360-371.


REVIEWS


Mital, J. and Ward, G.E. (2007) Current and Emerging Approaches to Studying Invasion in Apicomplexan Parasites.  In: Molecular Mechanisms of Parasite Invasion, Dominique Soldati and Barbara Burleigh-eds. Landes Bioscience.


Ward, G. E. , Chitnis, C. E., and Miller, L. H. (1994) Invasion of Erythrocytes by Malarial Merozoites. In Strategies for Intracellular Survival of Microbes (D. Russell - ed.), W.B. Saunders Co., London, pp. 155-190.

 

Contact webmaster: gward@uvm.edu